Effect of dispersion state of the magnetic Fe3O4 nanoparticles on the thermal distribution in Hyperthermia
نویسندگان
چکیده مقاله:
Introduction: Magnetic nanoparticle (MNP) hyperthermia is a promising cancer treatment approach. It is based on the evidence that by injecting MNPs such as Fe3O4 in the tumor and subjecting them to an alternating magnetic field, they release heat, generating temperatures up to 42°C that can kill cancer cells by apoptosis, usually with lowest damage to normal tissue. In previous work the temperature distribution of an ordinary tumor over the different sizes of Fe3O4 MNPs with uniform dispersion in tumor was performed. The objective of this work is to evaluate the thermal distribution of MNPs in the tumor tissue using random and array geometries due to dispersion states of the inclusions. Materials and Methods: The bio heat transfer equation (BHTE) formulated by Pennes, describes thermal processes in the human body. Since finding the exact solution of BHTE for a complex system like tumor tissue is a challenging issue, so finite element method in the COMSOL Multiphysics software is used to capture more details in predicting the temperature distribution in tumor tissue during the hyperthermia therapy. Producing the random and array numbers for distribution of the MNPs into the tumor tissue was carried out with MATLAB software. Fe3O4 MNPs with the size of 100 nm with different distributions in the tumor were simulated and the temperature distribution of the tumor and normal tissue was calculated, taking into account the thermal conductivity, density, and heat capacity. Results: The distribution of temperature in the tumor depends on Fe3O4 MNPs distribution. Uniform distribution of MNPs has appropriate distribution in the tumor and normal tissue around it. And also the agglomeration of MNPs in the tumor tissue leads to non-uniformity of the temperature distribution of the inclusions. Conclusion: In this research, the temperature distribution of an ordinary tumor over the different distributions (random and array) of Fe3O4 MNPs was investigated via the finite element method. The bio heat transfer equation was used to calculate the thermal processes in the tumor and normal tissues around it. It should be taken into account the distribution states of the MNPs into the tumor tissue and its subsequently effects on the thermal distribution. Finally, results showed that uniform distribution of the magnetic nanoparticles into the tumor tissue exhibited more appropriated results.
منابع مشابه
the effect of taftan pozzolan on the compressive strength of concrete in the environmental conditions of oman sea (chabahar port)
cement is an essential ingredient in the concrete buildings. for production of cement considerable amount of fossil fuel and electrical energy is consumed. on the other hand for generating one tone of portland cement, nearly one ton of carbon dioxide is released. it shows that 7 percent of the total released carbon dioxide in the world relates to the cement industry. considering ecological issu...
the washback effect of discretepoint vs. integrative tests on the retention of content in knowledge tests
در این پایان نامه تاثیر دو نوع تست جزیی نگر و کلی نگر بر به یادسپاری محتوا ارزیابی شده که نتایج نشان دهندهکارایی تستهای کلی نگر بیشتر از سایر آزمونها است
15 صفحه اولthe effect of e-64 on the developmental competence of sheep cocs during in vitro maturation
in the present study, the effect of e-64 at different concentrations (0.5, 1, 5 and 10 µm) added to (1) the ivm medium on oocyte nuclear maturation and developmental competence of ovine oocytes, and (2) to the ivc medium on embryonic development of ovine embryos were investigated.
the effect of learning strategies on the speaking ability of iranian students in the context of language institutes
the effect of learning strategies on the speaking ability of iranian students in the context of language institutes abstract language learning strategies are of the most important factors that help language learners to learn a foreign language and how they can deal with the four language skills specifically speaking skill effectively. acknowledging the great impact of learning strategies...
the effect of authentic listening materials on the listening proficiency of efl learners in the intermediate level
having conducted the experiment and analysed the data, the researcher computed the groups mean scores and variances for the test relating to the research question. as the final atep, a t-test was conodonted for the hypothesis. as noted earlier, the significance level was determined at .05 and .01 respectively. the observed t-value was higher than the critical t-value at. 5 and .01 levels. conse...
15 صفحه اولthe effect of the record infancy in crimilly acts of guilties (in karaj city)
چکیده یکی از مهمترین دغدغه های بزرگ جوامع بشری، از دیر باز تا کنون که ذهن پژوهشگران و متخصصان بهداشت روانی و اجتماعی و دولتها رابه خود مشغول داشته، مسأله ی بزهکاری می باشد. شناخت کامل پدیده ی بزهکاری و بزهکار، علل وعوامل سقوط یک انسان، چگونگی درمان وی و درنهایت پیشگیری ازبزهکاری ودریک کلام سالم سازی یک جامعه، رسالت عظیم، انسانی ومقدسی می باشد که با بررسی شخصیت مجرم یعنی[ انسانی که تحت شرای...
15 صفحه اولمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ذخیره در منابع من قبلا به منابع من ذحیره شده{@ msg_add @}
عنوان ژورنال
دوره 15 شماره Special Issue-12th. Iranian Congress of Medical Physics
صفحات 128- 128
تاریخ انتشار 2018-12-01
با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023